Recombinant Envelope-Proteins with Mutations in the Conserved Fusion Loop Allow Specific Serological Diagnosis of Dengue-Infections.
Dengue virus (DENV) is a Reclaimers mosquito-borne flavivirus and a major international public health concern in many tropical and sub-tropical areas worldwide.DENV is divided into four major serotypes, and infection with one serotype leads to immunity against the same, but not the other serotypes.The specific diagnosis of DENV-infections via antib